We selected E. coli Nissle 1917 (EcN) as the chassis organism be cause of its long history of safe use in human populations and the availability of numerous tools for genetic manipulation in this spe cies (39). EcN is widely used in Europe as a probiotic under the brand name Mutaflor. The excretion profile of orally dosed EcN was re
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with an increasing incidence in developed countries. Recent reports suggest that modulation of the gut microbiota might be one promising therapy for MS. Here, we investigated whether the probiotic Escherichia coli strain Nissle 1917 (ECN) could modulate the outcome of experimental autoimmune
Inspired by the fact that probiotics colonized and grew in the mucus layer under physiological conditions, we developed a strategy for a super probiotic (EcN@TA-Ca 2+ @Mucin) coated with tannic acid and mucin via layer-by-layer technology. We demonstrated that mucin endows probiotics with superior resistance to the harsh environment of the
Strain CFT073 is a bona fide uropathogen, whereas strains 83972 and Nissle 1917 are harmless probiotic strains of urinary tract and faecal origin, respectively. Despite their different environmental origins and dispositions the three strains are very closely related and the ancestors of 83972 and Nissle 1917 must have been very similar to CFT073.
Improved understanding of the E. coli Nissle 1917-host interaction is improved by analyzing the gene expression pattern initiated by this probiotic in human and mouse intestinal epithelial cells. BackgroundThe use of live microorganisms to influence positively the course of intestinal disorders such as infectious diarrhea or chronic inflammatory conditions has recently gained increasing
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